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SLC2A1 promotes chemo-immunotherapy resistance in lung adenocarcinoma by modulating the AKT signaling pathway

2026-03-30

Abstract excerpt

<title>Abstract</title> <p>Chemo-immunotherapy has become a standard treatment for lung adenocarcinoma (LUAD), yet the development of dual resistance to platinum-based chemotherapy and PD-1/PD-L1 blockade severely limits durable clinical benefit. This study aimed to identify a unified molecular regulator that concurrently drives chemoresistance and immune evasion. scRNA-seq of LUAD clinical cohorts was performed...

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Literature Corpus work
fe40faba-e904-562f-864a-4d871c5a83b1
DOI
10.21203/rs.3.rs-8886496/v1
Open publication

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SLC2A1 promotes chemo-immunotherapy resistance in lung adenocarcinoma by modulating the AKT signaling pathwayDOI 10.21203/rs.3.rs-8886496/v1
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