Article

Transgenic T cell therapy targeting the glioblastoma stem cell antigen PTPRZ1 with a vaccine-induced, patient-derived T cell receptor

2024-08-09

Abstract excerpt

<title>Abstract</title> <p>Response to CAR-T cell therapy in glioblastoma (GB) patients is limited, particularly because of the paucity of cell surface immunotherapeutic targets or low antigen sensitivity. Moreover, tonic CAR signaling leads to T cell dysfunction eventually resulting in non-durable responses. T cell receptor-engineered T (TCR-T) cell therapy circumvents the latter limitation by allowing safe and...

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Literature Corpus work: 8795e6b1-8b35-5c8a-8fd4-6e953beb44f3
DOI: 10.21203/rs.3.rs-4782908/v1

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