Article

Comprehensive microRNA profiling of aging cartilage in the Dunkin-Hartley guinea pig model identifies key regulators of osteoarthritis progression

2026-03-27

Abstract excerpt

<title>Abstract</title> <p> Background Osteoarthritis (OA) is the leading cause of joint disability in the elderly, particularly affecting the knee. The molecular mechanisms underlying idiopathic, age-related OA remain unclear, and current therapies are largely symptom-targeted. MicroRNAs (miRNAs) are key regulators of cartilage homeostasis and inflammation, but most <italic>in vivo</italic> models fail to re...

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Literature Corpus work: 877b456f-757d-5ede-a005-d9ca7462cfc9
DOI: 10.21203/rs.3.rs-8914957/v1

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