Article

Genetic manipulation of an <i>Ixodes scapularis</i> cell line

2023-09-10

Abstract excerpt

Although genetic manipulation is one of the hallmarks in model organisms, its applicability to non-model species has remained difficult due to our limited understanding of their fundamental biology. For instance, manipulation of a cell line originated from the blacklegged tick Ixodes scapularis, an arthropod that serves as a vector of several human pathogens, has yet to be established. Here, we demonstrate the su...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8771ff9e-616a-5a12-936b-8be544d02191
DOI: 10.1101/2023.09.08.556855

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic manipulation of an <i>Ixodes scapularis</i> cell lineDOI 10.1101/2023.09.08.556855Read

Genome-wide CRISPR knockout cell screening platform for the disease vector tick species <i>Ixodes scapularis</i>Semantic proximity Read

An expanded genetic toolkit for inducible expression and targeted gene silencing in <i>Rickettsia parkeri</i>Semantic proximity Read

A CRISPR interference platform for selective downregulation of gene expression in <i>Borrelia burgdorferi</i>Semantic proximity Read

Inducible CRISPRi-based operon silencing and selective <i>in trans</i> gene complementation in <i>Borrelia burgdorferi</i>Semantic proximity Read

The E3 Ubiquitin Ligase XIAP Restricts Anaplasma phagocytophilum Colonization of Ixodes scapularis TicksSemantic proximity Read

Insights into tick-pathogen interactions – a single cell RNA sequencing approach of transcriptional changes during ehrlichial infectionSemantic proximity Read

Validation of a heat-inducible <i>Ixodes scapularis</i> HSP70 promoter and developing a tick-specific 3xP3 promoter sequence in ISE6 cellsSemantic proximity Read

p47 licenses activation of the immune deficiency pathway in the tick Ixodes scapularisSemantic proximity Read

Disruption of <i>Ixodes scapularis</i> anticoagulation by using RNA interferenceSemantic proximity Read

Development of a confinable gene drive system in the human disease vector Aedes aegyptiSemantic proximity Read

Development of a Confinable Gene-Drive System in the Human Disease Vector, <i>Aedes aegypti</i>Semantic proximity Read

Immune factor of bacterial origin protects ticks against host skin microbesSemantic proximity Read