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Article

Disruption of <i>Ixodes scapularis</i> anticoagulation by using RNA interference

26 Jan 2004

Abstract excerpt

Ixodes scapularis ticks transmit many pathogens, including Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti. Vaccines directed against arthropod proteins injected into the host during tick engorgement could prevent numerous infectious diseases. Salp14, a salivary anticoagulant, poses a key target for such intervention. Salp14 is the prototypic member of a family of potential I. scapularis...

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PMID: 14745044
DOI: 10.1073/pnas.0307669100

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