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Article

Let-7c restores radiosensitivity and chemosensitivity and impairs stemness in oral cancer cells through inhibiting interleukin-8.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jul 2018

Peng Chih-Yu, Wang Tung-Yuan, Lee Shiuan-Shinn, Hsieh Pei-Ling, Liao Yi-Wen, Tsai Lo-Lin, Fang Chih-Yuan, Yu Cheng-Chia, Hsieh Ching-Shui

Abstract excerpt

BACKGROUND: The let-7 family of microRNAs has been considered as tumor suppressors in various cancers; however, the role of let-7c in oral squamous cell carcinoma has not been determined yet. METHODS: In this study, phenotypical behaviors and the radio/chemoresistance were examined subsequent to overexpression of let-7c. In addition, the expression of let-7c in cancer stem cells (CSCs) was evaluated and the...

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Identifiers

PMID: 29582468
DOI: 10.1111/jop.12711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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