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Rapid response of lichen planus to baricitinib associated with suppression of cytotoxic CXCL13+CD8+ T cells

14 Nov 2024

Abstract excerpt

BACKGROUNDCutaneous lichen planus (LP) is a recalcitrant, difficult-to-treat, inflammatory skin disease characterized by pruritic, flat-topped, violaceous papules on the skin. Baricitinib is an oral Janus kinase (JAK) 1/2 inhibitor that interrupts the signaling pathway of IFN-γ, a cytokine implicated in the pathogenesis of LP.METHODSIn this phase II trial, 12 patients with cutaneous LP received 2 mg daily...

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PMID: 39541169
DOI: 10.1172/jci179436

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