Article

The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

2023-06-29

Abstract excerpt

Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In human, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, human GSDME is cleaved by CASP3 but not by CASP7. The underlying mechanism of this observation is unclear. In this study, we identified a pyroptotic pufferfish GSDME that was cleaved...

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Literature Corpus work: 86cfe301-8deb-5ad9-8c09-74e5c80c954e
DOI: 10.1101/2023.06.28.546966

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