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Chicken GSDME, a major pore-forming molecule responsible for RNA virus-induced pyroptosis in chicken

22 Nov 2024

Abstract excerpt

ABSTRACT Pyroptosis is an inflammatory type of programmed cell death that mainly depends on the formation of plasma membrane pores by Gasdermin D (GSDMD) in mammals. However, the genetic deficiency of GSDMD in chicken renders avian pyroptosis elusive. Here, we show that infection of DF-1 cells (a chicken cell line) with infectious bursal disease virus (IBDV) induced cell death associated with chicken GSDME...

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PMID: 39576037
DOI: 10.1128/jvi.01588-24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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