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Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection

23 Mar 2022

Abstract excerpt

Pyroptosis is an inflammatory form of programmed cell death that is executed by the gasdermin (GSDM)-N domain of GSDM family proteins, which form pores in the plasma membrane. Although pyroptosis acts as a host defense against invasive pathogen infection, its role in the pathogenesis of enterovirus 71 (EV71) infection is unclear. In the current study, we found that EV71 infection induces cleavage of GSDM E...

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PMID: 35339492
DOI: 10.1016/j.jbc.2022.101850

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