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Article

The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

14 Aug 2023

Abstract excerpt

Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, human GSDME is cleaved by CASP3 but not by CASP7. The underlying mechanism of this observation is unclear. In this study, we identified a pyroptotic pufferfish GSDME that was...

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PMID: 38489483
DOI: 10.7554/elife.89974

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