Article

FGF12 Modulates Cardiomyocyte Hypertrophy by Inhibiting GATA4-ERK1/2 Phosphorylation Through Altered Intracellular Localization

2023-12-22

Abstract excerpt

<h4>Background</h4> Hypertrophic cardiomyopathy (HCM) is a heritable pathological condition resulting from mutations in sarcomere-related proteins, leading to severe structural abnormalities without effective treatment options. Although reduced fibroblast growth factor 12 ( FGF12 ) expression is observed in HCM patients, its functional role remains unclear. <h4>Methods</h4> Employing immunoprecipitation (IP)-...

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Literature Corpus work: 86849829-ffaa-5bec-8f0a-3ee1c3d3d9bb
DOI: 10.1101/2023.12.20.572709

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