Article

Vitamin D Receptor Upregulates Tight Junction Protein Claudin-5 against Tumorigenesis

2021-04-30

Abstract excerpt

<h4>Background/Objective</h4> Tight junctions (TJs) are essential for barrier integrity, inflammation, and cancer. The TJ protein Claudin-5 in the epithelia forms paracellular barriers and pores for permeability. Vitamin D and the vitamin D receptor (VDR) play important roles in various cancers. Although VDR and Claudin-5 are all involved in colorectal cancer (CRC), it remains unclear if they are closely related...

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Literature Corpus work: 865c2e78-7c53-5f3a-9052-9e65c13f3caf
DOI: 10.1101/2021.04.29.441977

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