Article

Vitamin D receptor protects against dysbiosis and tumorigenesis via the JAK/STAT pathway in intestine

2020-02-19

Abstract excerpt

<h4>Background</h4> Vitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome. Human Vdr gene variation shapes the microbiome and VDR deletion leads to dysbiosis. Low VDR expression and diminished vitamin D/VDR signaling are observed in colon cancer. Nevertheless, how intestinal epithelial VDR is involved in tumorigene...

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Literature Corpus work: 36ef8019-74f7-5552-b08a-2a0b7aca9a10
DOI: 10.1101/2020.02.18.946335

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