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Evaluating the role of liquid biopsy to detect pathogenic DNA Damage Repair (DDR) gene alterations in metastatic prostate cancer

2025-06-10

Abstract excerpt

<h4>Background</h4> Metastatic prostate cancers frequently harbor pathogenic aberrations in DNA damage repair (DDR) genes, that confer sensitivity to PARP inhibitors (PARPi). Therefore, accurate identification of all eligible patients is needed. The development of circulating tumor DNA (ctDNA) testing alternative is promising as genomic testing of archived tissue leads to up to 30-40% failure rate in prostate canc...

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Literature Corpus work
865a860f-e3ea-5c39-a631-910256a84127
DOI
10.1101/2025.06.06.25328738
Open publication

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