Homologous recombination repair genetic testing variables and diagnostic paths for prostate cancer patients: a multicenter cohort study.

doi:10.1093/oncolo/oyaf395

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Article

Homologous recombination repair genetic testing variables and diagnostic paths for prostate cancer patients: a multicenter cohort study.

The oncologist - 1 Dec 2025

Incorvaia Lorena, Puglisi Mattia, Maruzzo Marco, Mammone Giulia, Caffo Orazio, Procopio Giuseppe, Antonuzzo Lorenzo, Rizzo Mimma, Conteduca Vincenza, Messina Carlo, Scagliarini Sarah, Maiorano Brigida, Santoni Matteo, Facchini Gaetano, Lipari Helga, Formisano Luigi, Stellato Marco, Basso Umberto, Rossetti Sabrina, Lai Eleonora, Arcara Carlo Carmelo, Bronte Enrico, Bazan Russo Tancredi Didier, Colletta Giovanni, Gristina Valerio, Pepe Francesco, Malapelle Umberto, Santini Daniele, Depetris Ilaria, Di Maio Massimo, Badalamenti Giuseppe, Bracarda Sergio, Russo Antonio

Abstract excerpt

BACKGROUND: Evidence on homologous recombination repair (HRR) mutation prevalence in prostate cancer (PC) patients and the diagnostic testing path to guide treatment remains limited outside of clinical trials. The objective of this study was to investigate the DNA source, type of tumor tissue, timing for testing in the patient's disease course, and rate of conclusive results in a real-world population. PATIENTS...

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PMID: 41330714
DOI: 10.1093/oncolo/oyaf395
PMCID: PMC12921449

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