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Prognostic Significance of Circulating Tumor DNA in Metastatic Prostate Cancer: A Systematic Review and Meta-Analysis.

Clinical genitourinary cancer - 1 Jun 2026

Ye Duming, Zhao Yimin, Yang Liying, Sun Xingyao, Cao Tianchong, Yuan Meicheng, Qiao Tianyue, Xing Ligang, Sun Xiaorong

Abstract excerpt

Circulating tumor DNA (ctDNA) is a minimally invasive biomarker that enables molecular profiling and prognostic stratification in cancer. This meta-analysis evaluated the prognostic significance of ctDNA in metastatic prostate cancer (mPC). PubMed, Web of Science and Scopus were searched from inception to September 15, 2025 for studies assessing ctDNA and survival in prostate cancer. Hazard ratios (HRs) for...

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Biomarkers, Tumor
Circulating Tumor DNA
CDK6 gene
Mutation
Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Progression-Free Survival

Prostatic Neoplasms

Source

Identifiers

PMID: 41966893
DOI: 10.1016/j.clgc.2026.102545

Genes

BRCA1
AR
CDK6
MYC
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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