Article

Profiling and targeting HOX-PBX dimers in adult and paediatric glioblastoma as a novel therapy

2018-01-01

Abstract excerpt

HOX genes encode a family of transcription factors that play an essential role in embryonic patterning during foetal development. These genes are reported to be aberrantly expressed in numerous cancers, including glioblastoma (GBM). Previous research indicates that HOX genes are overexpressed in GBM tumours compared to normal human astrocytes (NHA). Three Amino Acid Loop Extension Homeobox (TALE) proteins act as i...

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Literature Corpus work: 8651561a-ccc0-551d-b630-9d0ebdcd0b4d
DOI: 10.15126/thesis.00849922

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