Article

Quisinostat is a brain-penetrant radiosensitizer in glioblastoma

2022-11-10

Abstract excerpt

<h4>ABSTRACT</h4> In recent years, histone deacetylase inhibitors (HDACi) have garnered considerable interest for the treatment of adult and pediatric malignant brain tumors. However, owing to their broad-spectrum nature and inability to effectively penetrate the blood-brain barrier, HDACi have failed to provide significant clinical benefit to glioblastoma (GBM) patients to date. Moreover, global inhibition of HD...

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Literature Corpus work: 038a7e05-8def-579e-a0f3-86ed6f3acd0d
DOI: 10.1101/2022.11.09.515859

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