Article

Study Protocol for a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Desidustat Oral Tablet in Sickle Cell Disease: A Phase IIa Proof-of-Concept Evaluation

2025-10-16

Abstract excerpt

<title>Abstract</title> <p> <italic> <bold>Background:</bold> </italic> Sickle cell disease (SCD) is a genetic disorder characterized by chronic hemolysis and vaso-occlusive crises. Desidustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), has shown promise in treating SCD by stimulating erythropoietin production in a similar manner that happens in response to hypoxia, promoting ery...

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Literature Corpus work: 8643a080-c981-54b0-9e92-67c59f22d626
DOI: 10.21203/rs.3.rs-6911159/v1

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Study Protocol for a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Desidustat Oral Tablet in Sickle Cell Disease: A Phase IIa Proof-of-Concept EvaluationDOI 10.21203/rs.3.rs-6911159/v1Read

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