Article
Molecular insights into prognostic model for meningiomas treated with stereotactic radiosurgery: negative impacts of 1q gain on tumor control and survival.
Acta neuropathologica communications - 14 Nov 2025
Umekawa Motoyuki, Shinya Yuki, Hirano Yudai, Miyawaki Satoru, Hasegawa Hirotaka, Sakai Yu, Teranishi Yu, Ogawa Shotaro, Katano Atsuto, Komura Daisuke, Katoh Hiroto, Ikemura Masako, Ono Hideaki, Ushiku Tetsuo, Ishikawa Shumpei, Saito Nobuhito
Abstract excerpt
Molecular classifications enhance prognostic accuracy in meningiomas; however, their predictive significance following stereotactic radiosurgery (SRS) remains unclear. This study aimed to assess whether molecular characteristics identified by whole-exome sequencing (WES), specifically driver mutations and copy number alterations (CNAs), are prognostic indicators of outcomes after SRS. This retrospective cohort...
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