Article

Nano-scale viscometry reveals an inherent mucus defect in cystic fibrosis

2024-03-07

Abstract excerpt

Abnormally viscous and thick mucus is a hallmark of cystic fibrosis (CF). How the genetic defect causes abnormal mucus in CF remains unanswered and a question of paramount interest. Mucus is produced by hydration of gel-forming mucin macromolecules that are stored in secretory granules prior to release. Current understanding of mucin/mucus structure before and after secretion remains limited and contradictory mode...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8638d5df-0713-5e4b-b879-322fa82ee776
DOI: 10.1101/2024.03.06.583796

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nano-scale viscometry reveals an inherent mucus defect in cystic fibrosisDOI 10.1101/2024.03.06.583796Read

A General High-throughput Mucus Microrheology Platform For Personalized MedicineSemantic proximity Read

Statistical Methods for Microrheology of Airway Mucus with Extreme HeterogeneitySemantic proximity Read

Cystic fibrosis: An inherited disease affecting mucin-producing organsSemantic proximity Read

Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis ConditionsSemantic proximity Read

Biochemical and Biophysical Characterization of Respiratory Secretions in Severe SARS-CoV-2 (COVID-19) InfectionsSemantic proximity Read

Increased Low Molecular Weight Mucins in Muco-Obstructive Airway Disease Limit <i>Staphylococcus aureus</i> GrowthSemantic proximity Read

Quantitative Analysis of Cytoplasmic Viscosity in Colorectal Cancer Cells by Differential Dynamic Microscopy of Genetically Encoded NanoparticlesSemantic proximity Read

Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs.Semantic proximity Read

Optimizations of In Vitro Mucus and Cell Culture Models to Better Predict In Vivo Gene Transfer in Pathological Lung Respiratory Airways: Cystic Fibrosis as an ExampleSemantic proximity Read

A combinatorial biomolecular strategy to identify peptides for improved transport across the sputum of cystic fibrosis patients and the underlying epitheliaSemantic proximity Read

Structural mechanism of MUC5AC mucin net-like polymer formation and its SNP variability that affect risk of the lung diseases COPD and IPFSemantic proximity Read

AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.Semantic proximity Read