Article

A combinatorial biomolecular strategy to identify peptides for improved transport across the sputum of cystic fibrosis patients and the underlying epithelia

2019-06-04

Abstract excerpt

Drugs and drug delivery systems have to traverse multiple biological barriers to achieve therapeutic efficacy. In diseases of mucosal-associated tissues such as cystic fibrosis (CF), successful delivery of gene and drug therapies remains a significant challenge due to an abnormally concentrated viscoelastic mucus, which prevents ~99% of all drugs and particles from penetrating the mucus barrier and the underlying...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7f18feff-6f32-5024-9077-8ee863cbf820
DOI: 10.1101/659540

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A combinatorial biomolecular strategy to identify peptides for improved transport across the sputum of cystic fibrosis patients and the underlying epitheliaDOI 10.1101/659540Read

Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epitheliaSemantic proximity Read

Assisting PNA Transport Through Cystic Fibrosis Human Airway Epithelia With Biodegradable Hybrid Lipid-Polymer NanoparticlesSemantic proximity Read

Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis ConditionsSemantic proximity Read

Cystic Fibrosis: Overview of the Current Development Trends and Innovative Therapeutic StrategiesSemantic proximity Read

Pulmonary bacteriophage and cystic fibrosis airway mucus: friends or foes?Semantic proximity Read

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site-Specific Integration of CFTR and Mutation-Agnostic Disease RescueSemantic proximity Read

CFTR RNA- and DNA-based therapies.Semantic proximity Read

Optimizations of In Vitro Mucus and Cell Culture Models to Better Predict In Vivo Gene Transfer in Pathological Lung Respiratory Airways: Cystic Fibrosis as an ExampleSemantic proximity Read

Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrierSemantic proximity Read

Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosisSemantic proximity Read

Rapid and unbiased enrichment of extracellular vesicles via meticulously engineered peptideSemantic proximity Read

Novel Therapeutic Strategies Applied to Pseudomonas aeruginosa Infections in Cystic FibrosisSemantic proximity Read