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Article

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling.

Journal of cellular and molecular medicine - 1 Jan 2010

Blazkova Hana, Krejcikova Katerina, Moudry Pavel, Frisan Teresa, Hodny Zdenek, Bartek Jiri

Abstract excerpt

Cytolethal distending toxins (CDTs) are proteins produced and secreted by facultative pathogenic strains of Gram-negative bacteria with potentially genotoxic effects. Mammalian cells exposed to CDTs undergo cell type-dependent cell-cycle arrest or apoptosis; however, the cell fate responses to such intoxication are mechanistically incompletely understood. Here we show that both normal and cancer cells (BJ, IMR-90...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19650831
DOI: 10.1111/j.1582-4934.2009.00862.x
PMCID: PMC3837606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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