Article

Protein codes promote selective subcellular compartmentalization

2024-04-17

Abstract excerpt

Cells have evolved mechanisms to distribute ∼10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must efficiently assemble. Here, we demonstrate that proteins with shared functions share amino acid sequence codes that guide them to compartment destinations. A protein language model, ProtGPS, was developed that predicts with high performance the compartment l...

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Literature Corpus work: 8615d2b5-6ce5-5235-a5f0-c649a5673b0f
DOI: 10.1101/2024.04.15.589616

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