Article
Protein codes promote selective subcellular compartmentalization.
Science (New York, N.Y.) - 7 Mar 2025
Kilgore Henry R, Chinn Itamar, Mikhael Peter G, Mitnikov Ilan, Van Dongen Catherine, Zylberberg Guy, Afeyan Lena, Banani Salman F, Wilson-Hawken Susana, Lee Tong Ihn, Barzilay Regina, Young Richard A
Abstract excerpt
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. In this study, we demonstrate that proteins with shared functions share amino acid sequence codes that guide them to compartment destinations. We developed a protein language model, ProtGPS, that predicts with high performance the compartment...
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