Article
Prediction of disease-related mutations affecting protein localization.
BMC genomics - 23 Mar 2009
Laurila Kirsti, Vihinen Mauno
Abstract excerpt
BACKGROUND: Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein is...
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