Article

Spatial memory in Alzheimer’s disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330

2024-10-22

Abstract excerpt

<h4>ABSTRACT</h4> The proteostatic decline in Alzheimer’s disease is well established and improvement in proteostasis could potentially delay cognitive impairment. One emerging entry point to modulate proteostasis is the regulation of nucleo-cytoplasmic partitioning of proteins across the nuclear pore via karyopherins. The nuclear exportin XPO1 is a key regulator of proteostasis by driving the assembly of ribosom...

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Literature Corpus work: 85ab841b-7284-51c9-9f47-d8be599478ff
DOI: 10.1101/2024.10.21.619493

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Spatial memory in Alzheimer’s disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330DOI 10.1101/2024.10.21.619493Read

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