Article

Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

2025-10-12

Abstract excerpt

Tyrosine Kinase 2 (TYK2) is a genetically defined target for autoimmune disease, with first-generation inhibitors showing clinical success in some but not all associated indications. A deeper understanding of TYK2 structure-function, protein-ligand interactions, and the impact of human variants could inform next-generation therapeutics. Here, we applied Deep Mutational Scanning (DMS) to assess >23,000 amino acid s...

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Literature Corpus work: 85915e74-00e3-5db4-b143-f2e9dc2be828
DOI: 10.1101/2025.10.11.681520

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