Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease.

doi:10.7554/eLife.110149

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Article

Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease.

eLife - 10 Jun 2026

Howard Conor J, Abell Nathan S, Warneford-Thomson Robert R, Mahdavi Eden, Su Alan L, Resnick Carmen, Mohammed Nabil, Thompson Erin M, Holzinger Emily R, Catalano Katrina, Hukku Abhay, Mintier Gabriel A, MacKenzie Morgan, Jiang Bryan L, Barbosa Rabago Dora, Chan Angela, Ntimi Carolindah, Weiler Kaitlyn N, Wilson Stephen C, Maranville Joseph C, Sheth Payal R, Plenge Robert M, Kosuri Sriram, Dickel Diane E

Abstract excerpt

Tyrosine kinase 2 (TYK2) is a genetically defined target for autoimmune disease, with first-generation inhibitors showing clinical success in some but not all associated indications. A deeper understanding of TYK2 structure-function relationships, protein-ligand interactions, and the impact of human variants could inform next-generation therapeutics. Here, we applied deep mutational scanning (DMS) to assess...

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Identifiers

PMID: 42268925
DOI: 10.7554/eLife.110149
PMCID: PMC13252953

Genes

TYK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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