Article

In vitro and in vivo investigations into the interactions between the acyl glucuronide metabolite of diclofenac and serum albumin

2012-01-01

Abstract excerpt

Adverse drug reactions represent a major challenge to clinicians, healthcare systems, pharmaceutical companies and academia. With carboxylic acid drugs accounting for the most common class of drugs withdrawn from the market, the carboxylate pharmacophore has received much attention as a potential toxicophore. Direct glucuronidation of the carboxylate group, producing chemically unstable and protein reactive acyl g...

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Literature Corpus work: 8567a55a-1296-5cdc-92cd-a4e1f5ebe948
DOI: 10.17638/00010013

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