Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice

21 Jun 2019

Abstract excerpt

Dengue virus (DENV) induces strong T and B cell responses upon infection. Hence, it is difficult to determine the contribution of cell-mediated immunity alone in the long lasting protection against DENV infection and disease. Numerous CD4+ and CD8+ T cell epitopes have been identified, mainly in the non-structural proteins of DENV. Taking into account the immunogenicity and peptide sequence conservation among the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Mosquito-borne diseases and control
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31293584
DOI: 10.3389/fimmu.2019.01424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic MicePMID 31293584Read ↗

A mRNA-LNP vaccine against Dengue Virus elicits robust, serotype-specific immunitySemantic proximity Read ↗

A Dengue Virus Serotype 1 mRNA-LNP Vaccine Elicits Protective Immune ResponsesSemantic proximity Read ↗

Modified mRNA-LNP Vaccines Confer Protection against Experimental DENV-2 Infection in MiceSemantic proximity Read ↗

Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines: The Superiority of Nucleoside-Modified mRNA Encapsulated in Lipid Nanoparticles Vaccine PlatformSemantic proximity Read ↗

mRNA-LNP Vaccines Encoding for Dengue Optimized prM/ENV Proteins Induce Protective Immunity without ADESemantic proximity Read ↗

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primatesSemantic proximity Read ↗

Progress and challenges of mRNA vaccinesSemantic proximity Read ↗

Enhancement of the HIV-1-Specific Immune Response Induced by an mRNA Vaccine through Boosting with a Poxvirus MVA Vector Expressing the Same AntigenSemantic proximity Read ↗

Infectious disease mRNA vaccines and a review on epitope prediction for vaccine designSemantic proximity Read ↗

Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPsSemantic proximity Read ↗

A comprehensive investigation of Glycoprotein-based nucleic acid vaccines for Hantaan VirusSemantic proximity Read ↗

An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.