Article

Interaction modulation through arrays of clustered methyl-arginine protein modifications

2018-03-26

Abstract excerpt

Systematic analysis of human arginine methylation identifies two distinct signaling modes; either isolated modifications akin to canonical PTM regulation, or clustered arrays within disordered protein sequence. Hundreds of proteins contain these methyl-arginine arrays and are more prone to accumulate mutations and more tightly expression-regulated than dispersed methylation targets. Arginines within an array in th...

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Literature Corpus work: 8529522d-e40f-5870-814a-40f0fdf7427d
DOI: 10.1101/289041

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