Neuroprotection by Acrolein Sequestration through Exogenously Applied Scavengers and Endogenous Enzymatic Enabling Strategies in mouse EAE model

Abstract excerpt

We have previously shown that the pro-oxidative aldehyde acrolein is a critical factor in MS pathology, and the acrolein scavenger hydralazine (HZ) can suppress acrolein and alleviate motor deficits in a mouse experimental autoimmune encephalomyelitis (EAE) model. In this study, we found that in addition to hydralazine (HZ), phenelzine and dimercaprol, two structurally distinct acrolein scavengers, can mitigate mo...

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• Cannabis and Cannabinoid Research
• Cell Adhesion Molecules Research
• Demyelinating Diseases
• Locomotion
• Mice
• Mice, Inbred C57BL
• Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• NF-κB Signaling Pathways

Identifiers and source

Literature Corpus work

850ea3ef-c68b-56e8-9fee-4da2ed5662bd

DOI

10.21203/rs.3.rs-3266870/v1