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Bromelain Restores Glutamatergic Homeostasis via Regulation of NR2A, GLT-1, EAAC1, and xCT in Arsenic-Induced Cerebral Cortex and Hippocampal Neurotoxicity

2025-12-31

Abstract excerpt

<h4>Background: </h4> Chronic arsenic exposure interferes with hippocampal-dependent cognition through glutamate excitotoxicity, which in turn interferes with the regulation of receptors and transporters. Bromelain, a combination of proteolytic enzymes derived from Ananas comosus, is known to have neuroprotective effects; however, the mechanisms by which it counteracts glutamate-mediated toxicity in the brain are...

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Literature Corpus work
1a2de101-70c3-5677-8958-77b48a6136b8
DOI
10.12688/f1000research.169308.2
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Bromelain Restores Glutamatergic Homeostasis via Regulation of NR2A, GLT-1, EAAC1, and xCT in Arsenic-Induced Cerebral Cortex and Hippocampal NeurotoxicityDOI 10.12688/f1000research.169308.2
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