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Article

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

11 Apr 2016

Abstract excerpt

Autophagy promotes tumor progression downstream of oncogenic KRAS, yet also restrains inflammation and dysplasia through mechanisms that remain incompletely characterized. Understanding the basis of this paradox has important implications for the optimal targeting of autophagy in cancer. Using a mouse model of cerulein-induced pancreatitis, we found that loss of autophagy by deletion of Atg5 enhanced activation...

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PMID: 27068336
DOI: 10.1158/2326-6066.cir-15-0235

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