Back to search

Article

Genome-wide CRISPR screens identified <i>C18orf32</i> as a novel regulator of lipid metabolism that mediates PFOA-induced toxicity

2025-12-25

Abstract excerpt

Perfluorooctanoic acid (PFOA) remains a public health concern due to its persistence in the environment, despite global production bans. Epidemiological, animal, and in vitro studies have consistently linked PFOA exposure to hepatotoxicity characterized by lipid dysregulation; however, the molecular mechanisms underlying these adverse effects in humans remain poorly understood. To address this gap, we employed an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
84cc440a-5661-513a-a838-0e4d2d173d41
DOI
10.64898/2025.12.23.696201
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genome-wide CRISPR screens identified <i>C18orf32</i> as a novel regulator of lipid metabolism that mediates PFOA-induced toxicityDOI 10.64898/2025.12.23.696201
Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cellsSemantic proximity
Investigating fatty liver disease-associated adverse outcome pathways of perfluorooctane sulfonate using a systems toxicology approach.Semantic proximity
Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish ( Danio rerio )Semantic proximity
LIPOGRID: A HIGH-THROUGHPUT MULTI-OMICS PERTURBATION SCREEN DISSECTS THE GENETIC ARCHITECTURE OF LIPID METABOLISMSemantic proximity
Integrated Spheroid-to-Population Framework for Evaluating PFHpA-Associated Metabolic Dysfunction and Steatotic Liver DiseaseSemantic proximity
PFHpA alters lipid metabolism and increases the risk of metabolic dysfunction-associated steatotic liver disease in youth—a translational research frameworkSemantic proximity
Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish ( <i>Danio rerio</i> )Semantic proximity
Mining Public Toxicogenomic Data Reveals Insights and Challenges in Delineating Liver Steatosis Adverse Outcome PathwaysSemantic proximity
PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver DiseaseSemantic proximity
Deciphering per- and polyfluoroalkyl substances mode of action: comparative gene expression analysis in human liver spheroidsSemantic proximity
Investigating the mode of action for liver toxicity and wasting-like responses produced by high dose exposures to longer chain perfluoroacid substances (PFAS) using high throughput transcriptomicsSemantic proximity
Modeling PNPLA3-Associated NAFLD Using Human-Induced Pluripotent Stem Cells.Semantic proximity
Select a neighboring publication to make it the new centre.