Article

Quantitative proteomic alterations of human iPSC-based neuronal development indicate early onset of Rett syndrome

2019-04-10

Abstract excerpt

Rett syndrome (RTT) is a progressive neurodevelopmental disease often caused by mutations in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2). The mechanisms by which impaired MeCP2 induces the pathological abnormalities in the brain are not understood. To understand the molecular mechanisms involved in disease, we used an RTT patient induced pluripotent stem cell (iPSC)-based model and applied an i...

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Literature Corpus work: 84bf3ec3-9b33-52a5-b9d9-e10776a9a9bf
DOI: 10.1101/603647

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