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Article

Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors.

Molecular autism - 27 May 2020

Varderidou-Minasian Suzy, Hinz Lisa, Hagemans Dominique, Posthuma Danielle, Altelaar Maarten, Heine Vivi M

Abstract excerpt

BACKGROUND: Rett syndrome (RTT) is a progressive neurodevelopmental disease that is characterized by abnormalities in cognitive, social, and motor skills. RTT is often caused by mutations in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2). The mechanism by which impaired MeCP2 induces the pathological abnormalities in the brain is not understood. Both patients and mouse models have shown...

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Source

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Identifiers

PMID: 32460858
DOI: 10.1186/s13229-020-00344-3
PMCID: PMC7251722

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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