Back to search

Article

PU.1 Eviction at Lymphocyte-Specific Chromatin Domains Mediates Glucocorticoid Response in Acute Lymphoblastic Leukemia

2024-02-15

Abstract excerpt

<title>Abstract</title> <p>The epigenetic landscape plays a critical role in the onset and evolution of various malignancies, but its therapeutic utility remains underutilized. Glucocorticoids are an essential part of many multi-agent treatment regimens for lymphoid malignancies. However, the emergence of glucocorticoid resistance is a significant barrier to cure, which is in part due to epigenetic alterations, i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9b21dae5-a47d-55af-9548-4afa565a991a
DOI
10.21203/rs.3.rs-3872306/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PU.1 Eviction at Lymphocyte-Specific Chromatin Domains Mediates Glucocorticoid Response in Acute Lymphoblastic LeukemiaDOI 10.21203/rs.3.rs-3872306/v1
PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemiaSemantic proximity
Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemiaSemantic proximity
Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemiaSemantic proximity
Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemiaSemantic proximity
Research Resource: Transcriptional Response to Glucocorticoids in Childhood Acute Lymphoblastic LeukemiaSemantic proximity
Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemiaSemantic proximity
Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced deathSemantic proximity
Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cellsSemantic proximity
Molecular mechanisms contributing to glucocorticoid resistance in lymphoid malignanciesSemantic proximity
Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemiaSemantic proximity
Loss of TBL1XR1 Disrupts Glucocorticoid Receptor Recruitment to Chromatin and Results in Glucocorticoid Resistance in a B-Lymphoblastic Leukemia ModelSemantic proximity
Mutual antagonism between glucocorticoid and canonical Wnt signaling pathways in B-cell acute lymphoblastic leukemiaSemantic proximity
Select a neighboring publication to make it the new centre.