Article

The <i>MUC19</i> Gene: An Evolutionary History of Recurrent Introgression and Natural Selection

2023-09-25

Abstract excerpt

We study the gene MUC19 , for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants for the Denisovan-like MUC19 haplotype at high frequencies in admixed Latin American individuals, and at highest frequency in 23 ancient Indigenous American individuals, all predating population admixture with Eu...

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Literature Corpus work: 84894b34-e4dc-5ed2-879c-bac0f03c7f6b
DOI: 10.1101/2023.09.25.559202

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