Back to search

Article

A Denisovan-derived <i>Alu</i> insertion in <i>OCA2</i> contributes to pigmentation diversity in present-day Melanesians

2026-03-18

Abstract excerpt

<h4>ABSTRACT</h4> Modern humans inherited DNA from Neanderthals and Denisovans, but the contribution of introgressed structural variants (SVs) to present-day human phenotypes and adaptation remains poorly understood. Here, we used a graph-genome approach to genotype 96,277 SVs in 3,332 present-day humans and three high-coverage archaic hominin genomes, identifying 153 candidate introgressed SVs. These SVs are enr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b66c7de1-416f-5871-b57c-e4858b5eb161
DOI
10.64898/2026.03.18.712481
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Denisovan-derived <i>Alu</i> insertion in <i>OCA2</i> contributes to pigmentation diversity in present-day MelanesiansDOI 10.64898/2026.03.18.712481
Genomic diversity and post-admixture adaptation in the UyghursSemantic proximity
Deciphering complete archaic introgression sequences in modern human genomesSemantic proximity
Population Structure, Stratification and Introgression of Human Structural VariationSemantic proximity
A meta-analysis of ancient and present-day Central Eurasian genome data to revise archaic hominin ancestrySemantic proximity
A Refined Analysis of Neanderthal-Introgressed Sequences in Modern Humans with a Complete Reference GenomeSemantic proximity
The Genetics and Evolution of Human PigmentationSemantic proximity
Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population.Semantic proximity
Functional archaic DNA regulates molecular variation and is associated with disease risk across global populationsSemantic proximity
Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania.Semantic proximity
Whole genome sequence of Mapuche-Huilliche Native AmericansSemantic proximity
Insights on hair, skin and eye color of ancient and contemporary Native Americans.Semantic proximity
Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments.Semantic proximity
Select a neighboring publication to make it the new centre.