Article

Eight-Fold Increased COVID-19 Mortality in Autosomal Dominant Tubulointerstitial Kidney Disease due to MUC1 Mutations: An Observational Study

2024-09-03

Abstract excerpt

<title>Abstract</title> <p>Background <italic>MUC1</italic> and <italic>UMOD</italic> pathogenic variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD). <italic>MUC1</italic> is expressed in kidney, nasal mucosa and respiratory tract, while <italic>UMOD</italic> is expressed only in kidney. Due to haplo-insufficiency ADTKD-<italic>MUC1</italic> patients produce approximately 50% of normal mu...

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Literature Corpus work: 3d2d6a58-6561-5a15-bcd5-3a4b60a55b5f
DOI: 10.21203/rs.3.rs-4719483/v1

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