Back to search

Article

Overexpression of Alpha-1 Antitrypsin Increases the Proliferation of Mesenchymal Stem Cells by Upregulation of Cyclin D1 and is Independent of the Wnt Signaling Pathway

2023-10-28

Abstract excerpt

<h4>ABSTRACT</h4> Alaph-1 antitrypsin overexpressing mesenchymal stromal/stem cells (AAT-MSCs) showed improved innate properties with a faster proliferation rate when studied for their protective effects in mouse models of diseases. Here, we investigated the potential mechanism(s) by which AAT gene insertion increases MSC proliferation. Human bone marrow-derived primary or immortalized MSCs (iMSCs) or AAT-MSCs (i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
846c9825-8820-537e-bc5b-5dd001125df7
DOI
10.1101/2023.10.28.564526
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Overexpression of Alpha-1 Antitrypsin Increases the Proliferation of Mesenchymal Stem Cells by Upregulation of Cyclin D1 and is Independent of the Wnt Signaling PathwayDOI 10.1101/2023.10.28.564526
High-content analysis reveals senescence of cultured canine adipose-derived mesenchymal stromal cells to be reversible with a novel immortalization approachSemantic proximity
Inhibiting DNA methylation as a strategy to enhance adipose-derived stem cells differentiation: Focus on the role of Akt/mTOR and Wnt/β-catenin pathways on adipogenesisSemantic proximity
Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem CellsSemantic proximity
Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Reverses Type 1 Diabetes via Promoting Treg Function and CD8 <sup>+</sup> T cell exhaustionSemantic proximity
Immortalized Mesenchymal Stromal Cells Overexpressing Alpha-1 Antitrypsin Protect Acinar Cells from Apoptotic and Ferroptotic Cell DeathSemantic proximity
Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.Semantic proximity
Amniotic membrane‐derived cells inhibit proliferation of cancer cell lines by inducing cell cycle arrestSemantic proximity
Anti‐senescence effects of DNA methyltransferase inhibitor RG108 in human bone marrow mesenchymal stromal cellsSemantic proximity
RB Maintains Quiescence and Prevents Premature Senescence through Upregulation of DNMT1 in Mesenchymal Stromal CellsSemantic proximity
Automated image analysis detects aging in clinical-grade mesenchymal stromal cell culturesSemantic proximity
Cell Contact Accelerates Replicative Senescence of Human Mesenchymal Stem Cells Independent of Telomere Shortening and p53 Activation: Roles of Ras and Oxidative StressSemantic proximity
Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)–dependent TGF-β signalingSemantic proximity
Select a neighboring publication to make it the new centre.