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Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures

10 Jan 2018

Abstract excerpt

Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal stromal cells (MSCs) are known to be small and spindle-shaped but become enlarged upon cell aging. Indeed, cell morphology is routinely evaluated during MSC production using subjective methods. We have...

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PMID: 29321040
DOI: 10.1186/s13287-017-0740-x

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