Article
Simtuzumab Attenuates Loxl2-Mediated Extracellular Matrix Remodeling and Preserves Cardiac Function in LMNA Mutation-Induced Dilated Cardiomyopathy.
Circulation. Heart failure - 1 Apr 2026
Kervella Marie, Behrens Charlotta S, Peccate Cécile, Guesmia Zoheir, Grandi Fiorella, Mougenot Nathalie, Forand Anne, Charrabi Azzouz, Brochier Guy, Andriantsitohaina Ramaroson, Singh Sonia R, Eschenhagen Thomas, Meli Albano C, Muchir Antoine
Abstract excerpt
BACKGROUND: Dilated cardiomyopathy caused by LMNA mutations is a severe cardiac condition marked by arrhythmias, contractile dysfunction, and excessive myocardial fibrosis, which collectively impair left ventricular function and increase the risk of heart failure. Although the disease has been well characterized, a lack of insight into the pathogenesis has impeded the development of therapies. METHODS: Here, we...
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