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Article

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.

Nature communications - 20 Dec 2011

Stefan Eduard, Malleshaiah Mohan K, Breton Billy, Ear Po Hien, Bachmann Verena, Beyermann Michael, Bouvier Michel, Michnick Stephen W

Abstract excerpt

G-protein-coupled receptors sense extracellular chemical or physical stimuli and transmit these signals to distinct trimeric G-proteins. Activated Gα-proteins route signals to interconnected effector cascades, thus regulating thresholds, amplitudes and durations of signalling. Gαs- or Gαi-coupled receptor cascades are mechanistically conserved and mediate many sensory processes, including synaptic transmission,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits

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Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 22186894
DOI: 10.1038/ncomms1605
PMCID: PMC3247815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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