Article
Lung cancer in pulmonary fibrosis: tales of epithelial cell plasticity.
Respiration; international review of thoracic diseases - 1 Jan 2011
Königshoff Melanie
Abstract excerpt
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis. Pulmonary fibrosis is characterized by repetitive injury and subsequent impaired repair of epithelial cells, which leads to aberrant growth factor activation and fibroblast accumulation. Increased proliferation and hyper- and...
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