Article

Single-cell RNA-sequencing of PBMCs from SAVI patients reveals disease-associated monocytes with elevated integrated stress response

2023-04-27

Abstract excerpt

Gain-of-function mutations in STING1 , which encodes the Stimulator of Interferon Gene (STING), result in a severe autoinflammatory disease termed STING-associated vasculopathy with onset in infancy (SAVI). Although elevated type I interferon (IFN) production is thought to be the leading cause of the symptoms observed in patients, STING can induce a set of pathways, which roles in the onset and severity of SAVI, r...

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Literature Corpus work: 5f96cc74-076f-5a79-801a-55383533d47f
DOI: 10.1101/2023.04.25.23288913

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