Article

SATB2 Induces Malignant Transformation and Cancer Stem Cell Characteristics, and Inhibition of Its Expression Reverses Drug Resistance in Mesothelioma

2025-12-15

Abstract excerpt

SATB2 (special AT-rich binding protein-2) is a chromatin modifier and epigenetic regulator that regulates gene expression by acting as a transcriptional co-factor. The objective of this paper was to examine whether overexpression of the SATB2 gene is sufficient to induce cellular transformation in a human mesothelial cell line in vitro, and inhibition of its expression in cancer stem cells (CSCs) reverses drug res...

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Literature Corpus work: 83b40da8-f744-5522-a9a7-06567c994874
DOI: 10.20944/preprints202512.1282.v1

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